Gene drives

Resistance to natural and synthetic gene drive systems

This review summarizes our current understanding of the evolution of resistance to naturally-occurring and synthetically-created gene drives. We explore how insights from earlier work might help us deelop evolution-proof gene drives, better predict …

An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura

We measured the effects of a natural gene drive, _Sex Ratio_ (_SR_), on fitness in _Drosophila pseudoobscura_. We find that _SD_ is very costly, especially when homozygous, and that it also has transgenerational effects on offspring fitness and sex ratio. Using a model, we show that these effects may explain the frequency and clinal patterns of _SR_ in nature.

Fitness consequences of the selfish supergene Segregation Distorter

We measured the effects of a natural gene drive, _Segregation Distorter_ (_SD_), on fitness in _Drosophila melanogaster_. We find that _SD_ is very costly, especially when homozygous, and that it also has transgenerational effects on offspring fitness and sex ratio. Using a model, we show that these effects may explain the puzzling rarity of _SD_ in nature.

Evolutionary simulations of Z-linked suppression gene drives

This paper presents eco-evo simulations investigating the feasibility of a newly-proposed type of gene drive, the _W_-shredder. _W_-shredders might someday be used to control populations of pests and pathogens that have _ZW_ sex determination, such as Lepidopteran pests, parasitic trematodes, and cane toads.

Gene drives

Population genetics of natural and synthetic gene drives

The ecology and evolutionary dynamics of meiotic drive

Both naturally occurring and synthetic ‘meiotic drivers’ violate Mendel's law of equal segregation and can rapidly spread through populations even when they reduce the fitness of individuals carrying them. Synthetic drivers are being developed to …

Coevolutionary dynamics of polyandry and sex-linked meiotic drive

Segregation distorters located on sex chromosomes are predicted to sweep to fixation and cause extinction via a shortage of one sex, but in nature they are often found at low, stable frequencies. One potential resolution to this longstanding puzzle …

Even more functions of sperm RNA: a response to Hosken and Hodgson

As recently outlined in TREE [1], many animals and plants are thought to load their male gametes with multiple types of RNA, some of which enters the oocyte upon fertilization. Four classes of ultimate hypotheses for sperm RNA were proposed [1], …