Gene drives

Gene drives

Population genetics of natural and synthetic gene drives

The ecology and evolutionary dynamics of meiotic drive

Both naturally occurring and synthetic ‘meiotic drivers’ violate Mendel's law of equal segregation and can rapidly spread through populations even when they reduce the fitness of individuals carrying them. Synthetic drivers are being developed to …

Coevolutionary dynamics of polyandry and sex-linked meiotic drive

Segregation distorters located on sex chromosomes are predicted to sweep to fixation and cause extinction via a shortage of one sex, but in nature they are often found at low, stable frequencies. One potential resolution to this longstanding puzzle …

Even more functions of sperm RNA: a response to Hosken and Hodgson

As recently outlined in TREE [1], many animals and plants are thought to load their male gametes with multiple types of RNA, some of which enters the oocyte upon fertilization. Four classes of ultimate hypotheses for sperm RNA were proposed [1], …